the right move if you are the 1 seed at home is to save your ace. If you lose the first game, and you use your third or fourth starter, at least you still have your ace available for the elimination game against the 2 or 3 seeds #2 starter. And you also have your ace available in case the 2 or 3 seed saves their ace. Assuming you win the losers bracket game, you then can throw your #2 starter against the loser of the winners bracket #3. You do run into a disadvantage if you make it through the losers bracket because then you are down to your #4 (or #3 if he didn't pitch the opener) and #5 starter.
But more than likely the #1 seed will win, and then you have your ace going against a 2 or 3 seeds #2, and then you can throw your #2 starter in the Championship round.
Also, I still stand by if you are a 1 seed at home and you can't beat a 4 seed with your #3 or #4, you probably shouldn't win that Regional anyway. You have got to take care of business.</p>