Harbortown is cool and there are some complexes that are gated. There is a small grocery store there but it’s very overpriced. Most people I know living downtown drive to Southaven or East Memphis to grocery shop, because the Kroger in midtown is an absolute cluster.
I lived in Collierville in some solid apartments for a while and enjoyed it. Quiet, great town, but probably not the best option if you’re gonna be barhopping a lot. East Memphis living was good. Never had any issues or felt unsafe. Plenty of food and store options. Not the best bars in town, but it’ll get you by on a midweek hang. Lots of young professional types living there.
I commute to work from Hernando now, and I love it. But if I were still in my 20s and single, I’d enjoy downtown or midtown while I can.