If your #2 or #3 starter can't beat a #4 like Bethune-Cookman, you probably don't deserve to win the Regional anyway.
I guess my thinking with the 2 and 3 seed is you want to try to stay in the winners bracket as long as possible, so you go ahead and pitch your ace, and if you win and the #1 holds back their ace, that's the way it goes. A lot of teams have #2 starters that can match up fairly well with another teams ace, so I guess you hope that you have a Gene Morgan type guy. Plus, if you pitch your #2 against Ole Miss and get beat, then you have to make a decision on whether you want to pitch your ace against Bethune-Cookman, because if you get upset, by B-C, you would have a lot of explaining to do to the media on why you didn't pitch your ace in the Regional at all.
Sometimes, you just have to use your intuition, use the data that you're given about the other teams that you're facing, and hope it works out. If what you do works, you're a genious, if it doesn't, you're an idiot.</p>