For me it was by Mike Reid in the 1969 game versus Colorado which we won 27 to 3. We received the opening kickoff in which Charlie Pitman injured his one ankle because a Colorado player twisted his foot in making the tackle. Reid went on a tear when Colorado got the ball; it lasted the whole game. Colorado QB who was substituting for the regular QBs swore that he would never play QB again.
I think the Colorado QB was Bob Anderson, who later was a DB in the NFL. That's off the top, so confidence level of "meh".
Reid also completely took over the previous season's Orange Bowl vs. Kansas when they were up 14-7 in the 4th. He was in on the Kansas QB, Bobby Douglass (lefty who played for the Bears for many seasons), and forced him into errant throws and disrupted the running game, which was led by John Riggins. Reid may have also partially blocked the punt that resulted in us getting the ball in decent field position (around midfield) for the game winning drive. From there, Chuck Burkhart's long pass to Bobby Campbell that took us down inside the Kansas 5 yard line. With just seconds to play, on 3rd down, we scored, went for two, KU was penalized for 12 men, we went for two again, and made it. Replays later showed that KU had 12 men on the field for that goal line sequence, iirc, and the refs didn't notice til the 2-point conversion.
Reid had any number of dominant games from his DT position that could be considered in this topic. He and Steve Smear were 10 years ahead of the other other-worldly pair of DTs at PSU, Clark and Millen.
