2025 NCAA Tournament: Men's National Championship Odds updated ahead of Sweet 16

by:Nick Kosko•about 13 hours•

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The latest national championship odds for the 2025 NCAA Tournament are in ahead of the Sweet 16 of March Madness. There are some clear favorites remaining, but others could surprise.

All four No. 1 seeds are still alive, as well as three of the four No. 2 seeds. Cinderellas? Not many this year!

There is some high quality basketball remaining and to get to the national championship will only be more difficult. Let’s dive into the latest odds, via FanDuel.

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Duke (+220)

The top seed in their bracket, Duke is the favorite to win the national championship at this point. The odds aren’t close actually.

With the way Cooper Flagg and company are getting it together, it’ll be tough to stop this freight train. There’s a potential matchup with Alabama in the Elite Eight.

Florida (+430)

Florida Gators head coach Todd Golden and Florida Gators guard Will Richard (5) huddle up during the second half against the Connecticut Huskies in the second round of the NCAA Tournament at Lenovo Center. (Bob Donnan-Imagn Images) — (Bob Donnan-Imagn Images)

Switching over to the SEC, Florida is the odds on favorite to win the national championship, not named Duke. After dominating in the first round, Florida edged out UConn in the Round of 32.

It could’ve been a disaster if they lost in the second round, but perhaps this proves the Gators are battle tested. Florida has Maryland in the Sweet 16 and are the favorite, perhaps all the way to the title game.

Auburn (+480)

The No. 1 overall seed came in slumping, but are still one of the favorites to win the national championship. Back to back double digit wins highlighted the first two rounds for the Tigers.

Next up is Michigan and potentially Michigan State back to back. Those will be grinds of games trying to get to the Final Four.

Houston (+550)

Houston grinded out a win over Gonzaga to get to the Sweet 16 but seemingly have a difficult path to a national championship. Still, the Cougars are one of the top four favorites to win it all.

Next up is Purdue in the Sweet 16 and if Houston wins, Kentucky or Tennessee awaits in the Elite Eight. But the path could go through Duke or Alabama on the top side in the Final Four as well.

Tennessee (+1,600)

Speaking of Tennessee and the national championship, the Vols have to beat Kentucky first in order to get to the Elite Eight. As referenced above, Tennessee has Houston in their part of the bracket.

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Still, if Tennessee can get through these next two games, we’re sure they’d welcome the challenge of a team like Duke. Through the first two rounds, the Vols had controlling wins over Wofford and UCLA.

Alabama (+1,700)

Alabama is back on track with two wins over Robert Morris and Saint Mary’s. Right? Well, they have deficient odds to win the national championship.

BYU upset Wisconsin so they’re in the way of the Crimson Tide next. Even with a win, Alabama likely has to get through Duke in the Elite Eight in order to have a shot at a national title.

Texas Tech (+1,900)

Texas Tech is on the same side of the bracket as top seeded Florida and gets Arkansas in the Sweet 16. The Red Raiders are still in the top half of the teams that have the best odds for the national championship.

A win over Arkansas gives Texas Tech either Florida or Maryland. There’s a path here, but it’ll be difficult for the Red Raiders.

Michigan State (+2,500)

Michigan State head coach Tom Izzo applauds after a play against Oregon during the first half of Big Ten Tournament quarterfinal at Gainbridge Fieldhouse in Indianapolis, Ind. - Junfu Han, USA TODAY Sports — Junfu Han, USA TODAY Sports

Let’s not forget about Michigan State when it comes to the national championship conversation. The Spartans rolled through Bryant and New Mexico to get to the Sweet 16.

Ole Miss is going to be a tough opponent for the Sweet 16 and they could see rival Michigan or top seeded Auburn in the Elite Eight. Talk about a tough path just in the region.