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Duke vs. Houston odds: Current line, win probability, final score prediction, how to watch NCAA Tournament

Grant Grubbs Profile Pictureby:Grant Grubbs03/30/25

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Duke vs. Houston Final Four odds how to watch channel
© Vincent Carchietta & © Troy Taormina-Imagn Images

Not every story ends with a Cinderella at the ball. On April 5, 1-seed Duke and 1-seed Houston will square off in the Final Four inside the Alamodome in San Antonio, Texas.

Duke punched its ticket to the Final Four with a stunning 85-65 blowout win over Alabama. All eyes are on freshman Cooper Flagg, who is a frontrunner for National Player of the Year and is projected to be the No. 1 pick in the upcoming NBA Draft.

Alas, the Blue Devils aren’t the only ones with elite talent. Houston looked dominant against the Volunteers on Sunday, holding Tennessee to a mere 15 points in the first half. In turn, FanDuel published the odds for Duke-Houston before the buzzer even sounded in the Cougars’ Elite Eight showdown.

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Odds for Duke vs. Houston

According to FanDuel, Duke is a 5.5-point favorite against Houston. Additionally, the Blue Devils boast -230 odds on the money line.

The over/under for the game is set at just 135.5 points. For reference, Duke is averaging 82.7 points per game in comparison to Houston’s 72.2 points per outing.

Final score prediction for Duke vs. Houston

KenPom Predicted final score: 68-66
KenPom Win probability (for Duke): 57%

KenPom is a predictive system for college basketball. It’s designed to show how strong a team is at a given time without taking factors like injuries into account. KenPom is slightly less confident in Duke than Las Vegas. The system is only favoring the Blue Devils by two points.

How to watch Duke vs. Houston

Time: 8:49 p.m. ET, April 5
Channel: CBS
Location: Alamodome — San Antonio, TX

1-seed Duke and Houston will meet on Saturday, April 5, in the Alamodome in San Antonio, Texas, for a highly-anticipated Final Four matchup. The winner will advance to the National Championship.

The Blue Devils are no strangers to the big game. Duke has appeared in the National Championship 11 times and won it five times, most recently in 2015. Meanwhile, Houston has only ever made two National Championship appearances and never won the title.

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