Isaac Guerendo injury update: 49ers RB to undergo tests, feared to have sprained foot

The San Francisco 49ers have had a devastating season with regards to injuries to their running backs. They were down to their third string running back on Sunday, Isaac Guerendo, and he suffered an injury in their win over the Bears. According to Myles Simmons of Pro Football Talk, the former Louisville star had to exit their game with a foot injury.

Following the game, 49ers head coach Kyle Shanahan called it a “Possible foot sprain,” via David Bonilla of 49erswebzone.com. “X-Rays didn’t for sure show anything, so we’ll have to look into it more tomorrow,” the 49ers head coach said on Sunday evening.

The 49ers finally found some positive momentum on Sunday, thrashing the Chicago Bears 38-13. Guerendo actually had over 120 all-purpose yards and two touchdowns, before exiting the game with his injury. Brock Purdy completed 20 of 25 passes for 325 passing yards, while tossing in two touchdowns with no interceptions. The 49ers outgained the Chicago Bears 452 total yards to 162 total yards.

This year for the 49ers Guerendo had 57 carries for 324 rushing yards and four touchdowns. As a receiver, he’s hauled in eight catches for 69 receiving yards.

Guerendo put together a big year in 2023 after transferring to Louisville, finishing with 810 rushing yards and 11 touchdowns in his lone season with the Cardinals. At Wisconsin, he served in a reserve role, he totaled 582 rushing yards and six touchdowns across four years.

Up next, the 49ers will take on the LA Rams on Thursday night, December 12th, on Thursday Night Football on Amazon Prime.

On3’s Nick Schultz also contributed to this article.