Louisville at Notre Dame odds: Early point spread released, How to Watch

One of the most exciting matchups in Week 5 of the college football season is a high-stakes, ranked game between No. 15 Louisville and No. 16 Notre Dame. A rematch of a thrilling upset win at home for Louisville last year that the Fighting Irish host this time around.

Saturday will represent the biggest test of the season for Louisville as they enter the game undefeated. Looking to continue building on their unexpected ACC Championship game appearance last season amid year two under Jeff Brohm. While Notre Dame looks to bolster up their resume and return to the College Football Playoff conversation following their upset loss to Northern Illinois in Week 2.

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DraftKings Sportsbook currently has Norte Dame set as five-point favorites (-5) ahead of this weekend’s matchup. Also setting the over-under at 48 points in a matchup that features two defenses that have stood out so far this season.

After losing their last three games of the season last year, Louisville hasn’t only won their first three games to start this season. But have also covered the spread in each of their matchups to start the year. A feat that the Fighting Irish have only achieved in half of their four games so far this season against the spread.

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How to Watch Louisville vs. Notre Dame

Time: Saturday 9/28 | 3:30 p.m. ET
Channel: Peacock
Location: Notre Dame Stadium – Notre Dame, IN

This weekend will be just the fifth time that Notre Dame and Louisville have squared off on the football field in the history of both programs. A series that will see a tiebreak this weekend, with the all-time series currently standing at 2-2.

Both offenses feature new transfer quarterbacks and several other key players who were not featured in last year’s matchup. As the stage is set for what could potentially be one of the most exciting Week 5 games of the week.