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Purdue vs. Houston odds: Current line, win probability, final score prediction, how to watch NCAA Tournament

On3 imageby:Dan Morrison03/23/25

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Kelvin Sampson, Houston. Matt Painter, Purdue
Kelvin Sampson, Houston. Matt Painter, Purdue - © Gregory Fisher-Imagn Images & © Nick Tre. Smith-Imagn Images

The NCAA Tournament is advancing to the Sweet Sixteen. There, the Purdue Boilermakers and the Houston Cougars are lined up to take on one another in what should be an excellent matchup.

Purdue, a four-seed in the NCAA Tournament, has yet to see a team that wasn’t a double-digit seed. In those games, the Boilermakers faced excellent upset bids, but ended up walking away with multiple double-digit point wins. Houston, meanwhile, came into the tournament as a one-seed and got all it could handle from Gonzaga in the second round, winning a tight game to avoid the major upset.

All eyes will be on Houston and Purdue in the Sweet Sixteen. Ahead of that game, here’s a look at the odds, current line, win probability, and how to watch the game.

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Odds for Purdue vs. Houston

Coming into the game, Houston is a 7.5-point favorite over Purdue, per FanDuel. The Cougars are also currently listed at -365 for the moneyline right now, while the Boilermakers are sitting at +285.

The point total for the game is currently set at 131.5 points. In the first two rounds of the NCAA Tournament, Purdue went over that number twice while Houston went over it just once.

Final score predictions for Purdue vs. Houston

BPI Predicted winner: Houston
BPI Predicted point differential: 8.5
BPI Win probability (for UH): 79.4%
BPI Matchup Quality: 90.7

ESPN’s BPI is a model designed to provide a statistical comparison between two teams and predict future success. It agrees with Vegas about what to expect from this game. Leading into the game, BPI is projecting a point differential of 8.5 points in Houston’s favor. It also gives the Cougars a 79.4% chance to win the game over the Boilermakers.

BPI also gives this game a matchup quality score of 90.7. That makes it one of several exciting matchups in the Sweet Sixteen.

KenPom Predicted final score: Houston 71, Purdue 64
KenPom Win probability (for UH): 73%

KenPom is another predictive system for college basketball. It’s designed to show how strong a team is at a given time, without taking factors like injuries into account. For this game between Purdue and Houston, KenPom agrees with BPI and Vegas, projecting the Cougars win by about seven points while scoring a total of 135 points.

How to watch Purdue vs. Houston

Time: 10:09 p.m. ET
Channel: TBS/TruTV
Location: Lucas Oil Stadium | Indianapolis, IN

The Purdue Boilermakers and Houston Cougars are set to tip off at 10:09 p.m. ET. It will be played at Lucas Oil Stadium in Indianapolis, an NFL stadium. There, these two basketball powerhouses will square off in the Sweet Sixteen. For fans who can’t make the game, it will be available on TBS and TruTV.

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