You can do a better job of keeping hitters off balance (in my opinion) by switching up the type of pitchers you throw. If I had a rotation that consisted of Lynn, Pigott, and Satterwhite: I'd throw Lynn of Friday, Pigott on Saturday, and Satterwhite on Sunday. Not because Pigott is better, but because I am now throwing a finesse, crafty left hander between two right handed guys that stay in the 90's. I think this would do a great job of keeping hitters off balance with the contrast in pitching styles.
But like I said, this is just what I would do.