One guy who caught lightning in a bottle that you couldn’t wait to see what he pulled out of his a$$ every week was Johnny Football. Now that was some fun.
But I went back and gave it some more thought to answer the OP‘s question properly. Offensively for me it was OJ both in college and pros. He and Gale Sayers were the first two guys I saw where their speed literally jumped through the TV. OJ‘s 2k season still was the most memorable individual season I ever saw.
Defense, it’s easier. LT. I really don’t remember seeing him much in college, but holy hell was unleashed in the NFL. The Fearsome Foursome, Purple People Eaters, and Steel Curtain were each memorable (and what amazing names), but LT was another level. I actually felt bad for the opposing QB. Fear is the only word to describe it.