If there is going to be a big talking point after the final seedings - I think that is the most likely one to cause a big kerfluffle (for 48 hours, until the next cause celebre).
IU getting stomped would present the committee with: "IU, or a fifth SEC team?"... depending on how the remainder of the SEC schedule plays out, that could be, let's say, Tennessee or Ole Miss.
There would be a lot of talk in favor of the Tenn/Ole Miss choice (and my gut feel is they would go with the extra SEC team - but who knows).
Compound that with - if you keep IU in the rankings if they get whacked by OSU - assuming two of PSU/OSU/Oregon end up 5 and 6 in the slotting (pretty likely two of those three end up in the 5/6 slots, which ones depending on the outcome of the Big10 CCG) - keeping IU in the bracket, which would likely be at 11 or 12, would mean either PSU/IU, or an OSU/IU rematch, or IU/Oregon in round 1. No one (aside from IU fans) wants to see that. If they do keep IU under those circumstances, they would probably have to monkey with the slottings (though they would never admit it) in order to match up IU w a non-Big10 team.