College Football odds: Point spreads released for every Week 4 game

A quarter of the regular season has come and gone. The Las Vegas oddsmakers are using early results to reformulate their odds across college football. Looking ahead to Week 4, most teams are diving into their conference slates and hoping to avoid the dreaded bad beat.

Week 3 action didn’t provide nearly as much drama as Week 2 did, with none of the top 10 teams losing a game on Saturday. However, Michigan State, which was previously No. 11, was not as lucky. The Vegas oddsmakers set the line at Washington -2.5, and the Spartans did not beat the odds, falling 39-28 to the Pac-12 foe.

Oregon and Texas A&M both beat more highly ranked programs in BYU and Miami, although they came into the battles as the favorites in Vegas. Meanwhile, programs like Arkansas, Florida and Wake Forest struggled failed to hit the spread versus G5 opponents.

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The schedule for Week 4 features top-25 battles between Arkansas and Texas A&M, Tennessee and Florida, and Clemson-Wake Forest. While the Aggies and the Vols are the favorites to beat their SEC foes at home, the traveling Clemson Tigers are -7 versus the Demon Deacons.

Check out the full slate of odds for games in Week 4.

College Football Week 4 odds, per Vegas Insider:

Thursday, Sept. 22

West Virginia at Virginia Tech (+2.5)
Coastal Carolina at Georgia State (+2.5)

Friday, Sept. 23

Virginia at Syracuse (-8.5)
Nevada at Air Force (-17.5)
Boise State at UTEP (+15)

Saturday, Sept. 24

Maryland at Michigan (-17)
Baylor at Iowa State (-1)
USF at Louisville (-13)
Clemson at Wake Forest (+7)
Buffalo at Eastern Michigan (-4.5)
Missouri at Auburn (-6.5)
Kent State at Georgia (-41.5)
Bowling Green at Mississippi State (-29)
Central Michigan at Penn State (-26.5)
TCU at SMU (+1)
Duke at Kansas (-9.5)
UCLA at Colorado (+21)
UMass at Temple (-9.5)
JMU at Appalachian State (-9)
Minnesota at Michigan State (-2)
Texas at Texas Tech (+4.5)
Notre Dame at North Carolina (+1.5)
Middle Tennessee at Miami (-27)
Indiana at Cincinnati (-14)
Florida at Tennessee (-10)
Toledo at San Deigo State (+1)
North Texas at Memphis (-13)
Tulsa at Ole Miss (-19.5)
Georgia Tech at UCF (-18)
Oregon at Washington State (+6)
Arizona at Cal (-4)
Akron at Liberty (-28)
Navy at East Carolina (-17.5)
Ball State at Georgia Southern (-8)
Arkansas State at Old Dominion (-3.5)
Rice at Houston (-17.5)
Arkansas at Texas A&M (-2)
Northern Illinois at Kentucky (-25)
Southern Miss at Tulane (-12)
Marshall at Troy (+4)
Louisiana Tech at South Alabama (-13)
Iowa at Rutgers (+7.5)
UNLV at Utah State (+2.5)
Wisconsin at Ohio State (-18.5)
FAU at Purdue (-18)
UConn at NC State (-38.5)
New Mexico at LSU (-31)
Vanderbilt at Alabama (-37.5)
Charlotte at South Carolina (-22)
Miami (OH) at Northwestern (-6)
Louisiana at ULM (+11)
Boston College at Florida State (-16)
Hawaii at New Mexico State (-2)
Kansas State at Oklahoma (-13)
USC at Oregon State (+6.5)
Wyoming at BYU (-23.5)
Stanford at Washington (-12.5)
Western Michigan at San Jose State (-3.5)
Utah at Arizona State (+14)

Odds updated on Sept. 18, 2022.