ESPN College GameDay: Picks for Week 4, Ohio State at Notre Dame

College GameDay brought ESPN’s iconic pregame show to South Bend, Indiana on Saturday, ahead of the Notre Dame Fighting Irish welcoming the Ohio State Buckeyes for a gigantic showdown.

With quarterback Sam Hartman leading the charge, Notre Dame believes they have a tremendous shot at defeating the Buckeyes. Both teams have designs on making it to the College Football Playoff, and can inch closer to their goal with a win.

Elsewhere, the Week 4 slate is one of the best we’ll see all season long. Florida State versus Clemson starts the afternoon off, with Colorado at Oregon and Ole Miss at Alabama holding down the fort until kickoff of Ohio State at Notre Dame under the lights.

Joining the crew as the Celebrity Guest Picker was none other than Vince Vaughn. The Hollywood staple is a huge fan of the Fighting Irish, and even had a role in Rudy back in the beginning of his acting career, so it’s an awesome moment for Vaughn.

With an exciting Week 4 on the docket, here’s who the College GameDay crew believes will come out on top this weekend.

CGD Predictions for Week 4:

Ohio State Buckeyes at Notre Dame Fighting Irish: Howard started things off by pleasing the crowd with his pick of the Fighting Irish, while Herbstreit brought them back down by picking the Buckeyes. McAfee re-energized South Bend by going with Notre Dame, and of course Vaughn is rolling with them.

As for Corso’s head-gear pick, Brutus was his first love, as we all know. It’s tough to go against your first love, and that’s who he’s rolling with, as Corso picked the Buckeyes.

Florida State Seminoles at Clemson Tigers: In an ACC matchup with gigantic implications, McAfee is the only one to ride with Dabo Swinney and the Tigers.

Colorado Buffaloes at Oregon Ducks: Deion Sanders has Colorado rolling, but only Vaughn has the gumption to pick the Buffaloes.

Oregon State Beavers at Washington State Cougars: In an underrated Pac-12 showdown, only Herbstreit believes in the DJ Uiagalelei and the Beavers.

UCLA Bruins at Utah Utes: Utah won’t have starting quarterback Cam Rising, and only Howard believes the Utes can overcome that loss.

Iowa Hawkeyes at Penn State Nittany Lions: It’s the white-out at Penn State, and nobody is picking against the Nittany Lions. Believe in Drew Allar.

Michigan Wolverines at Rutgers Scarlet Knights: In Jim Harbaugh’s return to the field, McAfee is the lone dissenter, believing in the Scarlet Knights to pull a monster upset.

Ole Miss Rebels at Alabama Crimson Tide: Can Lane Kiffin get his victory over Nick Saban? Howard and Corso believe in the Rebels.

UCF Knights at Kansas State Wildcats: Herbstreit, Vaughn and Corso believe UCF can go into Kansas State’s home and leave victorious.

BYU Cougars at Kansas Jayhawks: Vaughn and Corso believe in the Cougars to get the win.

Oklahoma Sooners at Cincinnati Bearcats: The Sooners travel to take on the Bearcats in a Big 12 showdown, and the whole crew believes Dillon Gabriel gets his long elusive victory over Cincinnati.

SMU Mustangs at TCU Horned Frogs: In the Battle of the Iron Skillet, McAfee and Herbstreit believe the Mustangs leave victorious.

Full CGD analyst picks for Week 4: 

Desmond Howard: Notre Dame, Florida State, Oregon, Washington State, Utah, Penn State, Michigan, Ole Miss, Kansas State, Kansas, Oklahoma, TCU

Pat McAfee: Notre Dame, Clemson, Oregon, Washington State, UCLA, Penn State, Rutgers, Alabama, Kansas State, Kansas, Oklahoma, SMU

Celebrity Guest Picker — Vince Vaughn: Notre Dame, Florida State, Colorado, Washington State, UCLA, Penn State, Michigan, Alabama, UCF, BYU, Oklahoma, TCU

Lee Corso: Ohio State, Florida State, Oregon, Washington State, UCLA, Penn State, Michigan, Ole Miss, UCF, BYU, Oklahoma, TCU

Kirk Herbstreit: Ohio State, Florida State, Oregon, Oregon State, UCLA, Penn State, Michigan, Alabama, UCF, Kansas, Oklahoma, SMU