OK, so I've been down this path. Started looking for 2, one for daily carry (for me), one for the wife's bedside drawer.
Started with two 9mm S&W's (M59's). Too heavy/bulky for me, too complicated for her. Fun to shoot, though. And cheap.
Went through a Glock (meh, rubbed blisters on my thumb), Sig, finally a 1911. I _love_ the 1911. Fits my hand well and makes me grin ear-to-ear when shooting. Plus the added bonus of being a disciple of the Prophet John Moses Browning. But couldn't carry it. Went through several models, ending with a lightweight colt commander. Still felt like a brick.
Finally settled on revolvers. I carry a S&W j-frame ultralite .357 mag. She has a stainless K-frame next her bed. Both are simple to operate, share common ammo, shoot .38 (cheap) and .357 (ammo availability), and very much the KISS principle. The j-frame is under a pound (unloaded) and just drops in my chino pocket w/o showing (decent pocket holser required $20). Plus, I have a Marlin 1984 lever rifle that's chamberd for .357, so in a SHTF situation, I've got three weapons that all share very commonly available ammo.
All that said, I dearly loved my 1911 and wish I still had it. But I can't abide a safe gun. If I don't use it, I don't keep it.
Anyhow, that's where we ended up. Your mileage may vary.