Smoked weed from when I was 17-21. Summer of 2001 buddy and I smoked some that was laced with something, we split one joint. We were riding backroads and I had an absolute panic attack, was trying to jump out of his truck. He finally pulled off in a field and I laid in the back of his truck for 30 minutes trying to calm down. That was pretty much it for me - smoked it a few more times, but never more than a couple of hits.
When I was 18 I remember coming close to trying meth. I had no clue what it was but guys I was with swore it wasn’t any worse than weed, just gives you a longer high. Thankfully the guy bringing it to the house we were at never showed up. I moved off to college few weeks later, most of those guys eventually turned into addicts. Last time I’ve seen any of them was at the funeral of one who OD’d ~10 years ago.