Alabama is generally less regional than Mississippi, from a geographical perspective anyway. Definitely has nothing as stark as the difference between the Delta and everything else.
One interesting thing is that you could move the entire north south MS-AL border 20 miles to the east, and nobody would know the difference. One might say that 20 x 300 mile strip is just a demilitarized buffer zone that was strategically placed by Alabama to trick Mississippians into thinking there was nothing very interesting to the east, so they’d turn around and go back home.
Beyond that, you have these regions that are kind of amorphous as to where they begin and end:
1) Tennessee Valley - everything from the Shoals to Bridgeport along the river. Goes all the way to the TN border to the north. To the south you get Guntersville, Albertville, Priceville, Decatur, and that’s about it. Huntsville is main hub of it all….you’ve got space, missiles, tech, outdoor stuff with lots of hiking and fishing and caves. This is the area with the most transplants from other states….the most fluid culture.
2) Sphere of Birmingham - consists of Birmingham and everything in a 30- mile radius. Cullman, Calera, Tuscaloosa, Pell City, Sylacauga, Jasper, Trussville. Outside of one of those having a major SEC university, it’s all the same shít. Birmingham is obviously a busier scene, and is the hub for the whole state and even moreso for those cities. But there’s not much separating the people / culture of that whole circle….inside or outside of Bham.
3) Prattville-Montgomery-Auburn / Opelika corridor. Kind of similar to the Rankin County-Jackson-Vicksburg corridor logistically, but a little more advanced with a major SEC metro area and what not.
4) The Alabama Emerald Coast - everything south of Interstate 10 and east of Mobile Bay. Real beaches. Foley, Daphne, Fairhope, Gulf Shores, OB, etc. Very different scene from the rest of the state, obviously. Does NOT include Mobile. Tourism capital of the state.
5) Mobile - it’s own scene entirely, but not necessarily in a bad way. It’s more similar to the MS coast or South LA than anywhere else in Alabama.
6) Deep Southeast AL - Dothan / Enterprise, etc. Nobody really knows what goes on down there, but they have peanuts and shít and people do actually live there. Tons of tax revenue from speed traps for folks on the way to Destin / 30A.
7) Southwest Alabama - Everything north and/or west of I-65, and south of I-20, until you get to Sphere of Birmingham. Just don’t.